TC Technology - Publications

TC Mouse and KM Mouse Publications

Tomizuka, K., et. al. "Double transchromosomic mice: Maintenance of two individual human chromosome fragments containing immunoglobulin heavy and kappa loci and expression of fully human antibodies"
Proc. Natl. Acad. Sci. USA, 97, 722-727, 2000.
Kuroiwa, Y., et. al. "Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts"
Nature Biotechnology, 18, 1086-1090, 2000.

Ishida, I., et. al. "Production of Human Monoclonal and Polyclonal Antibodies in TransChromo™ Animals"
Cloning and Stem Cells, Vol. 4(1), 91-102, 2002.
Shinohara, T., et. al. "Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome"
Human Molecular Genetics, 10, 1163-1175, 2001.
Shinohara, T., et. al. "Stability of transferred human chromosome fragments in cultured cells and in mice"
Chromosome Research, 8, 713-725, 2000.
Kuroiwa, Y., et. al. "Efficient modification of a human chromosome by telomere-directed truncation in high homologous recombination-proficient chicken DR40 cells"
Nuc. Acids Res., 26, 3447-3448, 1998.
Tomizuka, K., et. al. "Functional expression and germline transmission of a human chromosome fragment in chimaeric mice"
Nature Genetics, 16, 133-143, 1997.

Richt, JA, et. al. "Production of cattle lacking prion protein"
Nature Biotechnology, 25(1), 132-138, 2007.
Kuroiwa, Y., et. al. "Sequential targeting of the genes encoding immunoglobulin-µ and prion protein in cattle"
Nature Genetics, 36(7), 775-780, 2004.
Kuroiwa, Y., et. al. "Cloned transchromosomic calves producing human immunoglobulin"
Nature Biotechnology, 20(9), 889-894, 2002.